Breast Cancer in Young Women

It is quite common to see young women with breast lump worrying about cancer. This worrying should not be underestimated nor it should be blown out of proportion. Breast cancer in young women is uncommon. Again, one has to define what is young.

Definition of “young” is defined by different researchers as patients younger than 30, 35, 40 or even 50 years. This limits the amount of information you can gather because the number of cancers in each age group is not that high.

Here are few points to remember about young women who present with a breast lump.

Epidemiological studies in the U.S. show that 2.7 per cent of all cases of breast cancer occur in women ages 35 or younger and 0.6 per cent in women younger than age 30. According to a collective review article on this subject in the Journal of the American College of Surgeons (June 2008), women diagnosed at age 35 and younger tend to present at a more advanced stage of breast cancer and have poorer 5-yeare survival than older pre-menopausal women.

There are several concerns to be taken into consideration when a young woman is diagnosed with breast cancer. She will be worried about fertility, she will go into early menopause from the treatment and there will be psychological and emotional toll on the family, especially young children. The young lady will face a significant challenge to maintain her image and sexuality. The young patient needs to be treated as a whole and not as “just another patient with breast cancer.”

These days all patients (what ever their age or illness) are treated by multidisciplinary teams. The teams take into consideration all anxieties which may affect a patient’s treatment and outcome. But certain patients require special care and attention because of the uniqueness of their illness. Young women with breast cancers fall into that category.

Can we predict which young woman will get breast cancer?

The review article says there is currently no accurate tool for predicting breast cancer risk in young women. A Swedish population-based study found 48 per cent of women younger than 40 had a family history of breast or ovarian cancer. Another study has shown that breast cancer is less common in African-American women than Caucasian women but African-American women develop breast cancer at an earlier age and has worse prognosis than Caucasian women.

Why do young women present with later-stage breast cancers?

One of the reasons is that this population group is not screened as vigorously as the older women. Screening mammography is not recommended for women under 40 (low sensitivity and specificity due to dense breasts) and in fact it is controversial to screen women before the age of 50. In the last few years, some studies have discouraged women from doing breast self-examination (BSE). They argue that BSE leads to unnecessary biopsies.

The review article says, “Currently, it is recommended, although not specifically supported in the literature, that women with a family history of pre-menopausal breast cancer should begin mammographic surveillance 10 years before the age that their relative (i.e. mother, sister) was initially diagnosed.”

Some studies recommend doing an ultrasound alone or in combination with mammography to evaluate a breast lump in a young woman. There are other modalities being tried, such as digital mammography and MRI and these methods are showing promising results when one or more test are combined to evaluate a breast lump in a young woman.

The bottom line is, any suspicious dominant breast mass be biopsied even if the tests are negative. This principal applies whether the woman is young or old. Breast cancer in young women is uncommon but a breast lump in that age group should not be ignored but be thoroughly investigated.

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Did you know…

Did you know the death rate for breast cancer for Canadian women has dropped by 25 per cent since 1986?

A Canadian Cancer Society special report in Canadian Statistics 2007 says increased participation in organized breast screening programs (particularly by women aged 50 to 69) has led to earlier detection and made it more likely that patients who have breast cancer receive successful treatment (CMAJ June 19, 2007).

The national recommendation is that organized breast cancer screening programs actively screen women aged 50 to 69 every two years. Organized screening programs began in British Columbia in 1988 and have since expanded to include all provinces, the Yukon and the Northwest Territories.

If you are under 50 years of age or 70 and over then discuss your risks and screening program with your physician.

The screening program includes mammogram, clinical examination of your breasts by your physician every two years and monthly breast self-examination.

Did you know that early diagnosis and treatment of prostate cancer was first suggested a century ago?

Although prostate-specific antigen (PSA) blood test has been widely used in North America to detect early prostate cancer, it is still unknown whether PSA screening significantly reduces mortality from prostate cancer.

Actually PSA measurements reflect cancer risk, with the risks of cancer and of aggressive cancer increasing with the level of PSA (CMAJ June 19, 2007). Besides PSA blood level, your physician will look at other risk factors before he can advise you on further management. Other risk factors are: family history of prostate cancer, digital rectal examination findings, age, ethnicity and history of previous biopsy with a negative result.

Since PSA test is not a perfect test for detecting early prostate cancer, you should discuss with your doctor the risks and benefits of ordering such a test. PSA blood test for screening is not recommended by the Canadian Task Force on Preventive Health Care as there is insufficient evidence to promote it for screening for early detection of prostate cancer. Canadian Urological Association and Prostate Cancer Alliance have recommended that it be performed only after detailed discussion of the pros and cons between doctor and patient.

What is interesting is that recent nationwide survey indicated that almost half of Canadian men over 50 years of age reported receiving PSA screening during their lifetime. PSA blood test and digital rectal examination have become part of annual physical examination for men over 50 by their family physician and 72 per cent of these men had these tests in the last one year (CMAJ).

Prostate cancer is thought to be the disease of older men. But autopsy studies have found that 27 per cent of men in their 30s and 34 per cent of men in their 40s have histological evidence of the disease (not necessarily clinically known disease). The current lifetime risk of disease diagnosis is 18 per cent and lifetime risk of dying from prostate cancer is three per cent.

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Breast Cancer Awareness

October is breast cancer awareness month.

Today’s column will be little different. Read the question and ask yourself how much you know about breast cancer. Then read the answer and see if there is something new to absorb.

Q. How many women will develop breast cancer in the U.S.A, Canada and Australia?
A. In U.S.A., one out of every eight women will develop breast cancer in her lifetime compared to one in nine in Canada and one in 11 in Australia (TIME Magazine).

Q. Breast cancer rate in Palliser Health Region is higher than the provincial rate – true or false?
A. False. The incidence and mortality rates for breast cancer observed in our region are similar to the provincial rates (Cancer in Alberta 2005).

Q. What is the survival rate for women with early-stage breast cancer?
A. Nearly 98 per cent of women with early-stage breast cancer will live five years or more thanks to regular mammograms and improved treatments.

Q. What is Tamoxifen?
A. Tamoxifen is a drug which can lower a woman’s risk of breast cancer by 35 to 50 per cent. It reduces the risk of breast cancer recurrence and the chance of a new breast cancer starting. It can stop the progression of breast cancer (breastcancer.org).

Q. What is Herceptin (trastuzumab)?
A. It is a drug approved for the treatment of women with advanced-staged breast cancer. It also helps women with early-staged breast cancer by reducing recurrence rate by 50 per cent (CMAJ, August 16, 2005).

Q. What is Femara (letrozole)?
A. It is used by post-menopausal women who have finished five years of tamoxifen therapy after breast cancer surgery. The drug significantly reduces both the recurrence of breast cancer and distant metastases (CMAJ, March 24, 2005).

Q. How can a woman reduce the risk of breast cancer?
A. Drink alcohol in moderation, avoid obesity (obese women are twice as likely to die from breast cancer), women at risk for breast cancer should avoid estrogen hormonal therapy, do regular breast self-examination, have regular mammograms, have your physician check your breast once a year at least.

Q. Is antibiotic use associated with an increased risk of breast cancer?
A. A study published in 2004 suggested that premenopausal women who used antibiotics for urinary tract infections had an elevated risk of breast cancer compared with women who did not use antibiotics. The authors concluded that additional studies are required before the implications for clinical practice are clear. So, the jury is still out (CMAJ, June 22, 2004).

Q. Is exercise effective in reducing the risk of breast cancer in postmenopausal women?
A. Several articles have been published showing an association between physical activity and breast cancer prevention in post-menopausal women. It also helps in the reduction of cardiovascular disease and diabetes (CMAJ March 2, 2004).

Q. How reliable is mammogram in detecting breast cancer?
A. Sensitivity of mammogram depends on several factors. Overall sensitivity of mammogram is 70 to 90 per cent. It is only about 50 per cent in women under the age of 40. Less than 0.5 per cent of women will be found to have breast cancer on screening mammogram. If mammogram picks up a suspicious lesion then the chances of it being cancer on biopsy will be 90 per cent (CMAJ, January 18, 2006).

Q. Why do 35 per cent of women with locally advanced breast cancer wait more than three months before seeking medical attention?
A. Fear, belief that symptoms might be benign, belief there was nothing to worry about because they did not have a family history of breast cancer and belief they were too young to get breast cancer were cited by one in three women who eventually came to the Toronto –based clinic (The Medical Post, January 10, 2006).

So, how did you do?

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What’s New in Breast Cancer

Photograph shows a patient with advanced breast cancer.

Photograph shows a patient with advanced breast cancer.

Dear Dr. B: What’s new in breast cancer?

Answer: There are many good things happening in the field of breast cancer. To start with the prognosis is getting better. Nearly 98 per cent of women with early-stage breast cancer will survive at least five years. Most of these women will live a long healthy life.

But the bad news is the incidence of breast cancer is increasing. The numbers have been rising steadily since screening was established about 15 years ago. Because of the better screening methods more breast cancers are picked up at earlier stage with better cure rate. So, it is a mixture of bad news with good news. Without screening these cases would have eventually come to the surface (so to speak) probably with poor prognosis.

There is more good news. A recent trial showed Herceptin (trastuzumab), a drug used for late-stage breast cancer also helps women with early-stage breast cancer. The drug reduced recurrence of breast cancer by 50 per cent in early-stage breast cancer. It is useful in 20 to 30 per cent of these women whose tumours are HER2- positive.

Since 1999, Herceptin has been used in hospital setting for women with metastatic breast cancer. There was no funding for patients with non-metastatic breast cancer. It is an expensive drug. The annual cost of the drug per patient is $35,000-$45,000.

An article in the Canadian Medical Association Journal (Patient demand and politics push Herceptin forward) says some provinces have expanded funding for Herceptin to include non-metastatic breast cancer patients. The provinces are: British Columbia, Ontario, Saskatchewan and Quebec. Nova Scotia and PEI are extending availability on case-by-case basis. Women with breast cancer were happy to hear this. Alberta is in the process of finalizing the approval process.

All experts do not agree that such large amount of money should be spent on a small number of patients to gain few months of survival time. If the drug is curative then there would be no argument. But cure for cancer is no where in site. We just take baby steps and look for good news where ever we can find it. And there is no harm in experts debating issues. After all we live in a democracy. Let the best argument prevail.

The debate about the diagnostic accuracy of mammograms for screening purposes has been going on for many years. There is no dispute about the appropriateness of breast cancer screening in women aged 50-69 years. But the sensitivity of mammography in detecting breast cancer depends on the patient’s age, the size and location of the lesion, the hormone status of the tumour, and density of a woman’s breast, the overall image quality and the interpretative skills of the radiologist. So, mammography is good but not perfect.

What about obesity? Yes, weight gain increases breast cancer risk possibly due to excess estrogen derived from fatty tissue. Obese women are twice as likely to die from breast cancer. Women can reduce the risk of breast cancer by taking care of their weight. Studies have shown that there is an association between physical activity and breast cancer prevention. Physical activity also reduces the risk of cardiovascular disease and diabetes.

Those women who do not exercise regularly should take up the challenge. Most women do a great job looking after their families, but in the process they forget about themselves. An ounce of selfishness may be good for the rest of the family! As long as my dinner is ready when I come home!

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