Colonoscopy – A Dreaded Test Prevents Deaths

Colonoscopy cartoon. (Hemera)
Colonoscopy cartoon. (Hemera)

Dr. Bharwani demonstrating the use of flexible sigmoidoscope - checks left side of the colon for average risk patient.
Dr. Bharwani demonstrating the use of flexible sigmoidoscope – checks left side of the colon for average risk patient.

Rightly so, the media immediately picked up the conclusions of a recent study (Colonoscopic Polypectomy and Long-Term Prevention of Colorectal-Cancer Deaths) published in the New England Journal of Medicine (February 23, 2012).

Among 2602 patients who had adenomas (pre-malignant polyps) removed during participation in the study, after a median of 15.8 years, had 53 per cent reduction in death from colorectal cancer.

This indeed is an important conclusion. As New York Times (February 22/12) said, “Although many people have assumed that colonoscopy must save lives because it is so often recommended, strong evidence has been lacking until now.” This study has some limitations in that it was not a double blind or randomized trial.

The Times article also says, “The new study did not compare colonoscopy with other ways of screening for colorectal cancer and so does not fully resolve a longstanding medical debate about which method is best. Tests other than colonoscopy look for blood in the stool or use different techniques to examine the intestine. All the tests are unpleasant, and people are often reluctant to have them.”

In fact, a study from Spain found that when people were offered a stool test, only 34.2 per cent took it. The figure for colonoscopy was even worse: 24.6 per cent.

One thing most physicians agree is that it is important to get some type of screening test for colorectal cancer starting at age 50. Research indicates that not every polyp turns into cancer, but that nearly every colorectal tumor starts out as an adenomatous polyp. In the general population this type of polyp is found in about 15 per cent of women and 25 per cent of men.

So, not every 50 year old and older is at risk of having colorectal cancer. Some are at average risk, some are at moderate risk and some are at high risk. It all depends on your personal and family history.

Not all doctors who do colonoscopies are good at finding polyps. Studies have shown that polyps in the right side of the colon are more often missed than on the left side.

Good news is, colonoscopy does not have to be done every year. If there are no polyps, it is recommended just once every 10 years. People with polyps are usually told to have the test every three to five years depending on the size and kind of polyp.

Colonoscopy should be used judiciously. It is invasive and expensive. It carries small risks of bleeding or perforation of the intestine. It requires sedation, a day off work, and patients must take strong, foul-tasting laxatives to clean out the intestines.

Dr. Winawer, one of the authors of the new study is quoted in the Times article saying, “Any screening is better than none. The best test is the one that gets done, and that gets done well.”

So, what are you waiting for. Talk to your doctor about your risk (average, moderate, high), your options, the advantages and disadvantages of each test and go for it. It may save your life.

Honey, where is my bottle of laxative…I said laxative not a bottle of wine.

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There Isn’t One Best Treatment for Sleep Apnea

A man with sleep apnea using a CPAP machine. (iStockphoto)
A man with sleep apnea using a CPAP machine. (iStockphoto)

Noorali demonstrating CPAP

There are two main goals to be achieved when it comes to treating sleep apnea. First, to establish adequate ventilation. When you stop breathing your ventilation system stops. Second, to make sure your body gets enough oxygen.

There are three ways to treat the problem. Each treatment method has advantages and disadvantages. The treatment involves behaviour modification, medical treatment and sometimes surgical treatment.

For mild cases of sleep apnea, the treatment often starts with behavioural therapy. Counselling for behavioural changes includes losing weight and avoidance of alcohol, sleeping pills and sedatives. These pills relax throat muscles, contributing to the collapse of the airway at night.

Most patients snore sleeping on their back. These patients should be asked to train themselves to sleep exclusively on their side. One way to do this is by sewing three or four tennis balls at the back of an old shirt. Wear the shirt when you go to bed and you will never sleep again on your back. It will be painful. It works and it is cheap. This can prevent the tongue and palate from falling backwards in the throat and blocking the airway.

The medical management of sleep apnea uses continuous positive airway pressure (CPAP) or dental appliance.

For moderate to severe sleep apnea, the most common treatment is the use of a CPAP. CPAP is delivered through a mask to be worn when a sleep.

CPAP keeps the patient’s airway open during sleep by means of a flow of pressurized air into the throat. The patient wears a plastic facial mask (see picture), which is connected by a flexible tube to a small bedside machine. The CPAP machine generates the required air pressure to keep the patient’s airways open during sleep. The machine can humidify the air and keep it warm.

CPAP therapy is extremely effective in reducing the episodes of apnea. But some patients find it uncomfortable. The mask is not easy to fit your face and it is not easy to sleep with. One study demonstrated 46 per cent of patients used CPAP for more than four hours per night for more than 70 per cent of the observed nights. Others have adapted to CPAP quite nicely. Some studies have shown improved survival in patients who use CPAP.

Oral dental appliance has been promoted as a useful alternative to CPAP. It is a custom-made mouthpiece that shifts the lower jaw forward, opening up the airway. There are a variety of appliances. The appliances are worn only during sleep and are generally well tolerated. Not all patients have clinically proven response. It is considered as a second line of treatment compared to CPAP.

Surgical treatment for snoring and obstructive sleep apnea has become quite popular. Probably due to the inconvenience of CPAP and oral appliance. Surgery is considered if only other methods fail. Several surgical procedures are available, each one with advantages and disadvantages. These procedures are done by Otolaryngologists (specialists in ear, nose and throat surgeries).

There isn’t one solution to the problem of snoring and obstructive sleep apnea. Weigh your options carefully. Have yourself checked out at a sleep clinic and talk to a specialist in sleep disorders. Until then happy snoring.

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Sleep Apnea Disturbs a Good Night’s Sleep

A tired man who did not wake up when someone drew a mustache on his face! (Ulrik Tofte)
A tired man who did not wake up when someone drew a mustache on his face! (Ulrik Tofte)

Now that you are back from your Family Day long weekend, it is time to catch up with your sleep. But if you suffer from sleep apnea then you will never feel rested.

Normally, breathing is regular. Apnea means cessation of breathing. Sleep apnea is a condition that interrupts breathing during sleep.

Sleep apnea may be central – that is due to instability of the feedback system that regulates breathing. Or sleep apnea may be obstructive – due to recurrent obstruction of the upper airway. Or it can be mixed – central followed by obstructive.

Today, we will confine our discussion to obstructive sleep apnea.

A typical individual with obstructive sleep apnea starts snoring shortly after going to sleep. The snoring proceeds at a regular pace for a period of time, often becoming louder, but is then interrupted by a long silent period during which no breathing is taking place (apnea). The apnea is then interrupted by a loud snort and gasp and the snoring returns to its regular pace. This behaviour may recur repetitively and frequently throughout the night.

Obstructive sleep apnea causes frequent night awakening, feeling of tiredness in the morning, abnormal daytime sleepiness, headaches, memory loss, poor judgement, personality changes and lethargy. It may also raise the blood pressure.

Who suffers from obstructive sleep apnea?

Obstructive sleep apnea affects two percent of women and four percent of men. It is a condition of middle-aged adults.

Contributing factors may include obesity, use of alcohol or sedatives before sleep, anatomically narrowed airways, and massively enlarged tonsils and adenoids. Genetic and environmental factors may also adversely affect airway size. The condition may run in some families.

Diagnosis of sleep apnea is made by sleep study.

Is sleep apnea hazardous to your health?

During periodic breathing, there is a change in the amount of carbon dioxide and oxygen in the blood and this results in irregular heart rhythm, change in the blood pressure and in the autonomic nervous system. Heart failure, heart attack and stroke are likely complications.

Chronic sleep deprivation caused by sleep apnea increases risk for motor vehicle accidents. The accident rate for such patients has been reported to be seven times that of the general driving population.

In 1997, a review article in the British Medical Journal evaluated all studies published between 1966 and 1995 on the association between obstructive sleep apnoea and mortality and morbidity. The authors concluded that there was limited evidence of increased mortality or morbidity in patients with obstructive sleep apnea.

A report published recently in the American Journal of Respiratory and Critical Care Medicine found middle-aged and older men with untreated obstructive sleep apnea have more than double the risk of experiencing a stroke when compared with their counterparts who don’t have obstructive sleep apnea. Among women, an increased stroke risk was observed only among those with severe obstructive sleep apnea.

The paper concludes by saying that it is not known if treating obstructive sleep apnea reduces stroke risk but treatment offers a number of benefits, including greater alertness and less sleepiness in the day and improved concentration and memory.

Next week we will discuss treatment of sleep apnea. Until then sleep well.

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Valentine’s Day for Love, Roses, Chocolates and…may be Diamonds

Valentines gifts with chocolates. (Hemera)
Valentines gifts with chocolates. (Hemera)

Make love, not war.

If there is love, there is peace.

When you think about love, you think about peace, happiness and tranquility. But, as we all know, love is not as simple as we think. Turn on the news and there isn’t much love out there.

Sometime ago, I saw a movie called “Crazy, Stupid, Love.” It is a 2011 romantic comedy-drama film with Steve Carell, Ryan Gosling, Julianne Moore and others. It is a pretty complicated story involving many characters. In the end, you wonder what was it all about. It must have been about crazy, stupid, love. Yes, it was about crazy, stupid, love.

Next movie which comes to my mind is “Love Story.” It is a 1970 romantic drama starring Ryan O’Neal and Ali MacGraw. I remember the movie as real tearjerker. The film, well known as a tragedy, is considered one of the most romantic of all time by the American Film Institute. How can a love story be a tearjerker, a tragedy and most romantic? The word “oxymoron” comes to my mind. Yes, the movie was about love and sacrifice.

“Love means never having to say you’re sorry”, says Ryan O’Neal’s character at the end of the movie. What does that really mean? Well, true love is unconditional. True love is transparent. True love means we accept and understand and allow our loved one to make mistakes, falter and stumble. True love means we offer them genuine compassion when they are trying their best. Although, we may think their best has to be even “better.”

Patience, is a great virtue, when you love someone. To me, that really sums it up. Love means never having to say you’re sorry.

Valentine’s Day is a good day to reassure our loved ones that what counts most in the world is love and without that there is no happiness. Diamonds, roses and chocolates may provide some competition but love trumps them all.

That brings me to “chocolate theory of love.” You have to be a chemist to understand that. I will try to simplify it. I confess, I am not a chemist but I do love my dark chocolates.

In the early 1980s, researcher Michael Liebowitz, author of the popular 1983 book The Chemistry of Love, remarked to reporters that “chocolate is loaded with PEA.” This became the focus for an article in The New York Times, many magazines and wire services. It came to be known as “chocolate theory of love.”

PEA stands for phenylethylamine or phenethylamine. It is also the name of a class of chemicals with many members well known for psychoactive drug and stimulant effects.

Aside from PEA, there are many other ingredients in chocolates which cause chocolate craving, fight depression and anxiety, and increase energy and stamina among high performance athletes. PEA like amphetamine, is responsible for releasing the hormones dopamine and nor-epinephrine in the brain, making a person feel elated and uplifted.

Is it an aphrodisiac? You will have to find that out for yourself. See if the “chocolate theory of love” is true. But, remember, it is good for your heart and brain. Enjoy.

Have a wonderful Valentine’s Day.

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