What are the Long Term Consequences of Untreated Heartburn?

An empty operating room. (Hemera)
An empty operating room. (Hemera)

A case of hiatus hernia with severe reflux esophagitis - inflammation and ulcerations.
A case of hiatus hernia with severe reflux esophagitis – inflammation and ulcerations.

Heartburn is a symptom of gastroesophageal reflux disease (GERD). That means there is reflux of acid and bile from the stomach and duodenum into the esophagus. This irritates the esophagus and causes symptoms in the short term and damages the esophagus in the long run. Reflux may be associated with or without a hiatus hernia.

Children and adults are affected by this condition. Today, we will talk about adults with heartburn.

The most common symptoms of GERD are: heartburn, regurgitation and trouble swallowing. Less common symptoms are: pain with swallowing, increased salivation (also known as water brash), nausea and chest pain.

A person can have several other atypical symptoms associated with GERD. These symptoms are: chronic cough, laryngitis (hoarseness, throat clearing), asthma, erosion of dental enamel, dentine hypersensitivity, sinusitis, damaged teeth and pharyngitis.

If GERD remains untreated then there are serious consequences leading to injury of the esophagus. You don’t want that to happen to the only organ which carries food from your mouth to the stomach.

The damage starts with the condition called reflux esophagitis (see attached picture). Gastric acid and bile are toxic to the lining of the esophagus (epithelium) causing ulcers near the junction of the stomach and esophagus. This eventually leads to esophageal strictures – the persistent narrowing of the esophagus. It becomes difficult to swallow solid food and sometimes liquids if it is too narrow.

The next change occurs in the form of Barrett’s esophagus called intestinal metaplasia (changes of the epithelial cells from squamous to intestinal columnar epithelium) of the distal esophagus. This is a premalignant condition. The final chapter in this ongoing saga is headlined with that ugly word – cancer. What starts with a simple symptom of heartburn can transform into cancer. The progression is slow but can be persistent if heartburn is not treated.

Heartburn is a very common condition. Four to nine percent adults have heartburn daily, and another 10 to 15 percent have heartburn at least once a week. That means about 20 percent of the adults have heartburn on a weekly basis. Diagnosis is based mainly on symptoms.

Endoscopy is required if complications of GERD are suspected. Barium studies are also indicated in some instances.

Heartburn can be prevented by change in lifestyle: lose weight, change eating habits, avoid bending or straining, sleep with the head of the bed elevated (maximum damage to the esophagus occurs at night), no smoking, no alcohol, and take appropriate medications to neutralize or reduce acid in the stomach. Surgery is also an option in patients with intractable problems or complications of reflux.

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Antigua – A Beautiful Island with 365 Beaches

English Harbour and Falmouth Harbor, Antigua, Caribbean (Medioimages/Photodisc)
English Harbour and Falmouth Harbor, Antigua, Caribbean (Medioimages/Photodisc)

Antigua - beautiful sunrise
Beautiful sunrise.

Antigua - one of the many sports you can enjoy
One of the many sports you can enjoy.

Antigua - a beautiful view of the palm tree, beach and the ocean
A beautiful view of the palm tree beach and the ocean.

Antigua - the famous Half Moon Bay - from left to right - Hussein, Alia, Sabiya and Noorali Bharwani
The famous Half Moon Bay. From left to right: Hussein, Alia, Sabiya and Noorali Bharwani.

Antigua - Shirley Heights sunset
Shirley Heights sunset.

I love Antigua. You may wonder what is so exciting in Antigua that I should almost travel 24 hours to get there. From Medicine Hat to Calgary to Toronto to Antigua – yes it is a long way from where I am sitting at home. If I am looking for a direct flight with minimum number of changeovers then there is a choice of only one airline – Air Canada twice a week from Toronto to Antigua.

Apart from the inconvenience of a long flight for Westerners (Torontonians have to just hop over the ocean and be in Antigua), Antigua offers breathtaking beauty with blue waters, 365 beaches (one for each day of the year), good food, cocktails and relaxation. It is sunny and warm all year with soothing trade winds.

Antigua (pronounced an-TEE-gah) is an island in the West Indies. It has a circumference of 87 kilometers. It has a population of about 70,000. It is the largest of the Leeward Islands, and the most developed and prosperous due to its upscale tourism industry, offshore banking, internet gambling services and education services, including two medical schools.

The capital city is St. John with a population of 30,000. The island has an international airport (VC Bird International Airport) which is serviced by many major airlines. It has deep harbour to accommodate large cruise ships.

It has secluded, powdery soft beaches. The island is internationally famous for yachting and sailing. It has two 18-hole golf courses and they charge US$40 for green fees and US$30 for power cart. You cannot complain about that.

There is no shortage of enticing bars, Calypso music and Caribbean cuisine with peace and tranquility to go with it. It is a slow paced island, requires patience for pleasure and happiness. There is no shortage of soft adventures like scuba, snorkeling, boating, fishing, and much, much more.

In 1784, the legendary Admiral Horatio Nelson sailed to Antigua and established Great Britain’s most important Caribbean base. And now over 200 years later Antigua and Barbuda have become premier tourist destinations. Barbuda is just 15-minute flight or 90-minute ferry ride from Antigua. Barbuda has a 17-mile pristine and untouched pink shell beach. It is also a haven for seabirds.

Going to Antigua, you get to enjoy two islands in one. Not a bad deal. Except for me. In Barbuda, I was rock climbing and missed my step, fell and got a bad wound on my right leg. Being a surgeon, I had to fix it myself.

Antigua is home of one of the world’s foremost maritime events, Sailing Week. The coral reefs attract snorkelers and scuba divers from all over the world. There are several historic sites such as Betty’s Hope sugar mill, St. John’s Cathedral and Nelson’s Dockyard. You can tour the island in one day without any rush. And there is duty free shopping.

You have to spend one evening at Shirley’s Heights. It is a lovely hill with a view of Antigua’s southern coast. You can watch the sunset while drinking Jamaican rum. There is a barbecue every Sunday at 4:00 p.m. which is popular with tourists and locals. There is food, bar, music and dancing late into the night. Long live Shirley Heights!

Next time you are planning a holiday, say “Yaman, it is Antigua!”

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Research Shows Laughter and Music Good for Your Heart

A group of smiling women. (Goodshoot)
A group of smiling women. (Goodshoot)

In 2009, for the first time, research showed that there is some truth in the good old saying, “Laughter is the best medicine.” But anger and stress, hmm… not so good.

Laughter, along with an active sense of humour, may help protect you against a heart attack, according to the 2009 study by cardiologists at the University of Maryland Medical Center in Baltimore. The study found that people with heart disease were 40 percent less likely to laugh in a variety of situations compared to people of the same age without heart disease. They also displayed more anger and hostility.

The researchers could not explain how laughter protects the heart but they found that mental stress is associated with impairment of the lining of the blood vessels. The damage to the lining is followed by inflammatory reactions that lead to fat and cholesterol build-up in the coronary arteries and ultimately to a heart attack.

Now let us fast forward to 2011. Location: Paris, France. At a session entitled, “Don’t worry, be happy,” a series of research papers were presented at the European Society of Cardiology Congress highlighting the role of laughter, positive thinking (cognitive therapy), anger, and job stress on developing cardiovascular events.

The cardiologists from Baltimore presented their research related to the effects of humorous and stressful movies on the function of the lining of the blood vessels. They found that the blood vessels constricted by as much as 30 to 50 per cent when watching movies which were emotionally stressful. In contrast, blood vessels dilated when investigators measured vascular function in subjects watching the comedies.

Positive or negative effects on blood vessels can last for about an hour. Other researchers have seen the benefits of laughter on vascular function extended to 24 hours. The magnitude of change in the blood vessel is similar to the effects observed with statins and physical activity.

Other studies presented at the Paris conference dealt with the effect of anger, job stress, and depression. A study from University of Helsinki, Finland, observed that public-sector individuals who work more than three hours overtime per day were at an increased risk of coronary heart disease compared with those who worked no overtime.

A study from the Institute of Clinical Physiology in Pisa, Italy, recruited 228 patients with the diagnosis of myocardial infarction (heart attack), 200 of whom were men, and assessed the long-term effects of anger on recurrent cardiovascular outcomes. They found that over the course of 10 years, 78.5 per cent of patients without an angry-personality profile were free from a recurrent infarction compared with 57.4 per cent of patients with angry personalities. People with angry personalities tend to eat more and use alcohol too much to curb stress.

A study from Australia showed at four months, cognitive therapy reduced depression and reduced waist girth, increased good (HDL) cholesterol levels and increased physical activity. Patients were better at managing their anger, depression and anxiety.

A researcher from Germany, believes that classical music offers the ideal therapy for patients with hypertension and increased heart rates. He is now planning a prospective study called “Bach or beta blockers.”

Come to think of it, preventing heart attack is lot of fun. Laugh a lot, listen to music, have a positive attitude, meditate a bit, eat healthy, exercise regularly, have a glass of red wine, have a fulfilling relationship with your partner, go dancing and manage your anger. Easy.

Now, go and have some fun.

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A New Blood Thinner to Prevent Stroke

A doctor reviewing MRI films. (iStockphoto)
A doctor reviewing MRI films. (iStockphoto)

It was only a year ago, I wrote about a new blood thinner (dabigatran) to prevent stroke in patients with irregular heart rhythm. Now we have a second drug (rivaroxaban) for the same indication. This is good news for patients who are on blood thinners like warfarin – a rat poison.

About 350,000 Canadians suffer from irregular heart rhythm called atrial fibrillation (AF). In the U.S. there are approximately 2.3 million adults with AF. The commonest cause of AF is getting old. The lifetime risk of getting AF is one in four after the age of 45. Before that it is not that common. Occasionally, you do see patients in their 20s and 30s.

Most common causes of AF are: hypertension, valvular heart disease, alcohol excess, thyroid disease, obesity, sleep apnea, genetic predisposition and it can be idiopathic (cause unknown). What I call GOK – God only knows!

The most dangerous complication of AF is stroke. It accounts for up to 36 percent of all strokes in elderly people. The cost of looking after patients with stroke runs into millions of dollars.

In order to prevent stroke, patients with AF are converted to regular (sinus) rhythm by applying direct-current electrical shock (cardioversion), by medications or by ablation therapy. If it is difficult to sustain regular rhythm, then the patients receive blood thinners (like warfarin) on a regular basis to reduce the risk of stroke by 70 percent.

The main advantages of warfarin are that it is cheap and is covered by provincial drug plan. Major disadvantages are that you need frequent blood tests to make sure that the blood concentration of the drug is at a safe level to keep the blood thin. But not dangerous enough to make you bleed in the brain or some other place. It is quite difficult to achieve the safe level and maintain it.

Over the years, there has been great amount of research to find a drug to replace warfarin. Last year, dabigatran (Pradax) was introduced. This year we have rivaroxaban (Xarelto) in the market. These new blood thinners do not require regular blood tests.

Rivaroxaban is an oral blood thinner invented and manufactured by Bayer as Xarelto. Rivaroxaban is well absorbed from the gut and maximum inhibition of factor Xa occurs four hours after a dose. The effects last eight to 12 hours, but factor Xa activity does not return to normal within 24 hours so once-daily dosing is possible. Compared to dabigatran which is to be taken twice a day. The daily dose for rivaroxaban is usually 20 mg once a day.

The newer oral blood thinners have been found to be better in preventing stroke than warfarin and the risk of side-effects like bleeding is less than warfarin. And remember – no blood tests.

There are two significant disadvantages to taking the newer drugs. One, there is no antidote to convert your blood to normal if you have a significant bleed after trauma or bleeding due to another cause. The mortality rate can be high. Second, the pills are expensive. So, you have to check with your insurance company if the cost of the pills will be covered. Xarelto is slightly cheaper than Dabigatran because of once a day dosage.

Now, only if we can permanently prevent atrial fibrillation, warts, common cold and hemorrhoids (just to mention a few) then life will be good. You won’t have to choose between the devil and the deep sea. But some of us will be out of business.

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