Dear Dr. B: What is Sjogren’s syndrome?

Answer: Sjogren’s (pronounced “show-grins”) syndrome is a chronic autoimmune disorder in which body’s own antibodies (immune cells) attack and destroy the glands that produce tears and saliva. The syndrome was first described by Swedish ophthalmologist Henrik Sjögren (1899-1986). The syndrome is also associated with rheumatic disorders such as rheumatoid arthritis.

Why do our own immune cells turn against us? We don’t know. It may have some thing to do with our genes.

Patients with Sjogren’s syndrome present with dry mouth and dry eyes. The condition may also cause skin, nose and vaginal dryness. It may affect other organs of the body such as kidneys, blood vessels, lungs, liver, pancreas and brain.

The condition is more common between the ages of 40 and 60 but it may occur at any age. It is more common in females. About four million people in the U.S. are affected by Sjogren’s syndrome.

Because of the involvement of many organs, a patient may present with multiple symptoms. This makes diagnosis difficult. But there are several tests available to confirm the diagnosis of Sjogren’s syndrome.

Blood tests are done to check if a patient has high levels of antibodies. A strip of filter paper is used to check for production of tears. There is a test to check for dryness on the surface of the eyes A biopsy of the lip or salivary glands can be done to check for damaged cells.

Is there a cure for the problem? Unfortunately, no. There is neither a known cure for Sjögren’s syndrome nor a specific treatment to permanently restore gland secretion. Treatment is symptomatic and supportive such as artificial tears, goggles and increased local humidity to protect the eyes.

Medications are used to increase salivary flow. Steroids or immunosuppressive drugs are used for symptomatic relief of other symptoms. Prognosis for this condition is variable depending on the severity of the disease process.

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What is the most important meal of the day?

Most people know that the most important meal of the day is breakfast. It is the first meal of the day after prolonged overnight fast. A good breakfast should provide us with enough calories and should be healthy. It should curb our hunger later in the day so the total amount of calories consumed is less.

Dr. Khursheed Jeejeebhoy, a highly respected gastroenterologist and professor of medicine at the University of Toronto reviewed some literature and wrote an article in the Medical Post on this subject. He concluded that on the basis these studies, a good way to avoid overeating is to eat a breakfast rich in protein and fiber on a regular basis with fish meals thrown in. Fish protein is better than beef protein in reducing daily energy intake. So make it a point to enjoy a healthy breakfast everyday.

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Chocolate

Here is a picture of me admiring chocolate at Rocky Mountain Chocolate Factory in the Medicine Hat mall. In the background is Jody Jesse, assistant manager.
Here is a picture of me admiring chocolate at Rocky Mountain Chocolate Factory in the Medicine Hat mall. In the background is Jody Jesse, assistant manager.

There are two food groups: chocolate and fruit.
If it is fruit, it should be dipped in chocolate.
-from Chocolate Humour website

March was nutrition month. It has come and gone. Now what? Now it’s April and time for Easter eggs. Those yummy eggs full of nice tasting chocolate.

I like chocolate and once in a while I give in to dark chocolate. This happens more often when I am looking for instant energy. You may catch me eating chocolate on a ski hill, on a golf course or when I am travelling. But I do not look for a chocolate when I am busy at work.

Chocolate is made from roasted cacao beans. Hot chocolate drink has been around since Christopher Columbus and others brought cacao beans to Spain in 1521. In 1643, a Spanish princess took solid chocolate to France and chocolate became very popular all over Europe.

An average North American consumes about five to six kilograms of chocolate a year. Did you know 40 per cent of world’s almonds, 20 per cent of world’s peanuts and eight per cent of world’s sugar is used by chocolate manufacturers? No wonder too much chocolate is fattening.

There are three varieties of chocolates: dark, milk and white chocolate. Chocolate liquor is the main ingredient in dark and milk chocolate and white chocolate has no chocolate liquor.

Is chocolate good for us? Many studies have suggested moderate intake of chocolate (especially dark chocolate) is good for our heart and vascular system. This is surprising because chocolate contains about 30 per cent saturated fat. Saturated fat is known to raise bad cholesterol level. But chocolate has saturated fat which is poorly absorbed in the intestine. That is good news for chocolate lovers. Chocolate also improves blood flow and reduces blood pressure.

Besides being fattening, chocolate can cause dental caries. What about chocolate addiction, chocolate acne and chocolate migraine? There isn’t much scientific evidence to prove any of that. So once in awhile you can enjoy your chocolate.

Here are some trivia questions from the Internet:

-How do you get two kilograms of chocolate home from the store in a hot car? Answer: Eat it in the parking lot.

-If you eat equal amounts of dark chocolate and white chocolate, is that a balanced diet? Answer: I don’t know.

-Is it true that researchers have discovered chocolate produces some of the same reactions in the brain as marijuana? Answer: The researchers also discovered other similarities between the two, but can’t remember what they are…

Well, you will have to excuse me now, my heart needs a piece of dark heart shaped chocolate. Yummy…

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Lymph Glands

Dear Dr. B: What are the lymph glands? Why do I have lymph glands in the neck? Do I have cancer?

Answer: The lymph glands are also known as lymph nodes. A lymph node acts as a filter and is part of the lymphatic system. Tissues in the body release fluid called lymph. Lymph is transported through the lymphatic system, is filtered through the lymph nodes and the filtered fluid is then transported to the blood to maintain fluid balance.

Lymph nodes contain lymphocytes which destroy bacteria and viruses. When the body is fighting infection the lymph nodes produce more lymphocytes. The activity in the lymph node is increased and the node gets enlarged.

Our body has approximately 500-600 lymph nodes. They are found in the underarms, groin, neck, chest, and abdomen. They vary in size from few millimeters to couple of centimeters. Normally, they are not palpable on physical examination unless they enlarge due to infection or tumour.

Enlarged lymph nodes due to viral infection are “reactive” in nature and are usually small, firm and non-tender and they may not go away for weeks to months. Enlarged nodes due to bacterial infection are usually tender and more than a centimeter large. The most common site is the neck. These nodes get enlarged due to infection in the mouth, throat or the scalp. This may be associated with fever.

There are many other causes of lymph node enlargement such as: eczema, mono, tuberculosis, cat scratch disease, cancer (Hodgkin’s disease, non-Hodgkin’s disease, leukemia or metastatic cancer from other site).

A good history and physical examination is important in a patient presenting with persistent enlarged lymph node. This may give us a clue regarding the origin of the problem. Clinically, we may find that there is more than one area of enlarged nodes. The liver and spleen may be enlarged as well as they are part of the lymphatic system.

Patient is initially treated with 10 days of antibiotics. If the node does not respond to antibiotics then further investigations should be done to check for other causes of enlargement.

Blood tests, ultrasound and chest x-ray may give us more information. Finally, CAT scan, fine needle aspiration biopsy or open biopsy will be required to get to the bottom of the problem.

Whether you have cancer or not depends on how far the investigations have been done to answer this question. Clinical diagnosis of cancer is not always possible. Needle biopsy or open biopsy is usually necessary.

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Did you know that 25,000 Canadians die prematurely each year because of diet-related diseases? (CMAJ February 28, 2006).

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Gallstone Surgery

Dear Dr. B: Who needs treatment for gallstones?

Answer: Sooner or later all patients with gallstones need treatment. The treatment is surgery. The question is: should it be sooner or later?

Once upon a time, the surgical procedure of choice was open cholecystectomy. In fact, Langenbuch carried out the first cholecystectomy in 1882. Patients who undergo open cholecystectomy have a long surgical incision in the abdominal wall, have to stay in the hospital three to five days, consume fair amount of pain killers for post-operative pain and the recovery time at home is three to six weeks.

Things have changed in the last 15 to 20 years. Now most patients undergo laparoscopic cholecystectomy when there is an indication for surgical removal of the gallbladder. Laparoscopic cholecystectomy was first performed in France in 1987. In this procedure, there are four tiny incisions in the abdominal wall, the hospital stay is usually overnight, the amount of pain killers required after surgery is minimal and the recovery time at home is usually less than one week.

Prophylactic cholecystectomy is done only in few exceptional cases. Otherwise, gallstone surgery is required only if you have symptoms. The most common symptom is recurrent attacks of biliary colic. The colicky pain is in the upper abdomen usually on the right side. Sometimes the biliary colic can present as chest pain and some people think they are having a heart attack.

The timing of surgery depends on how often you get the attacks of pain. If you are getting recurrent attacks then the surgery is planned to be done within a few days. If you settle down after one or two attacks then the surgery can be done within a few weeks.

Second most common indication for surgery is complications of the disease such as acute cholecystitis and obstructive jaundice. In acute cholecystitis, the gall bladder is acutely inflamed and the patient undergoes urgent surgery, usually within 24 to 48 hours of hospitalization. If the gallbladder is very inflamed and the patient is very sick then the surgeon may elect to drain the gallbladder and plan further surgery to remove the gallbladder after three to six weeks.

In obstructive jaundice the gallstone is usually lodged in the common bile duct which effectively blocks the drainage of bile from the liver and the gallbladder to the small intestine. Patients with obstructive jaundice are not acutely sick but the blockage should be taken care of before patient undergoes surgery for the gallbladder.

Patients who have vague abdominal symptoms and are found to have gallstones (gallstone dyspepsia) need careful assessment to establish gallstones are indeed the cause of the symptoms. In some of these patients, the symptoms may be due to other causes such as irritable bowel syndrome or gastro-oesophageal reflux disease. Removing the gallbladder in these instances will not help.

In gallstone pancreatitis, a stone from the gallbladder passes through a common channel formed by the common bile duct and the pancreatic duct. In the majority of patients this results in a mild attack of pancreatitis and recovery is uneventful. The majority of stones that cause pancreatitis pass spontaneously. These patients should have laparoscopic cholecystectomy done during the same hospital stay.

Early surgery in these patients does not increase post-operative complications or mortality. Early surgery also eliminates the risk of recurrent attacks of pancreatitis while the patient is waiting for elective surgery. Patients with worsening pancreatitis require further investigations as the stone may be jammed in the common and pancreatic duct.

Cholecystectomy is a very common operation and appropriate timing of the surgery is very important for patient care and safety.

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