Uncontrolled Heartburn Leads to Serious Complications

Aga Khan Musoleum in Aswan, Egypt. (Dr. Noorali Bharwani)
Aga Khan Musoleum in Aswan, Egypt. (Dr. Noorali Bharwani)

About 10 to 20 per cent of the population has heartburn (gastroesophageal reflux disease – GERD).

Excessive reflux of acidic, often with alkaline bile salt and duodenal contents, results in a multitude of symptoms for the patient including heartburn, regurgitation, cough, and dysphagia.

There are also associated complications of reflux including erosive esophagitis, Barrett’s esophagus (a pre-malignant condition), stricture and cancer of the esophagus.

Your risk of heartburn and inflammation of the esophagus (esophagitis) increase if you have hiatal hernia, if you smoke, if you are pregnant, if you have scleroderma, or drink excessive alcohol. You should avoid food that’s acidic or high in fat – like citrus fruits, tomatoes, onions, chocolate, coffee, cheese, and peppermint. Spicy foods or large meals can also cause heartburn.

You shouldn’t worry about occasional heartburn. It is quite common. But frequent heartburn which does not respond to increased medications should be investigated. It is called refractory gastroesophageal reflux disease. Weight loss and difficulty swallowing are other red flags. Investigations should be carried out to see if you have complications like Barrett’s esophagus (a pre-malignant condition), strictures, esophageal ulcer, or bleeding.

Diagnostic tests required are as follows:

  • Upper endoscopy with biopsies – also known as gastroscopy (scope test) to check for infection, inflammation, ulcers or cancer. This is the first step in the diagnostic and therapeutic process.
  • Ambulatory acid (pH) probe test. A monitor is placed in your esophagus to identify when, and for how long, stomach acid regurgitates.
  • Esophageal manometry. This test measures the rhythmic muscle contractions in your esophagus when you swallow. Esophageal manometry also measures the coordination and force exerted by the muscles of your esophagus.
  • Barium x-ray of your upper digestive system.

Management of GERD

Common questions that arise regarding management of GERD include which medications are most effective with no side effects, when surgery may be indicated, which patients should be screened for Barrett’s esophagus and helicobacter pylori infection.

There are four primary treatment goals: 1. relief of symptoms, 2. prevention of relapse, 3. healing of inflamed esophagus, and 4. prevention of complications of esophagitis.

To start with, we should attempt to suppress gastric acid production and reflux into the esophagus. This is done by the use of lifestyle modifications (e.g., elevating the head of the bed, modifying the size and composition of meals) and use of appropriate medications.

Uncomplicated reflux can be managed with antacids that neutralize stomach acid. It may provide some relief but will not heal inflamed esophagus. Overuse of some antacids can cause side effects, such as diarrhea or sometimes kidney problems. In the absence of alarm symptoms, endoscopy is not necessary to make an initial diagnosis of GERD.

Persistent heartburn will require medications to reduce acid production. These medications (H-2-receptor blockers) include cimetidine (Tagamet HB), famotidine (Pepcid AC) and nizatidine (Axid AR).

Next line of management will be to use medications that block acid production and heal the esophagus. These medications – known as proton pump inhibitors (PPI) – are stronger acid blockers than H-2-receptor blockers and allow time for damaged esophageal tissue to heal. Examples include lansoprazole (Prevacid 24 HR) and omeprazole. PPI should be taken 30 to 60 minutes before the first meal. PPIs are the most effective medical therapy, and all PPIs provide similar relief of GERD symptoms.

It should be remembered that two common types of GERD medicines (H-2 receptor blockers and PPI) have been associated with B-12 deficiency to varying degrees. Also, there is a risk of hip fractures. With either type of medication, the risk of B-12 deficiency was significantly increased when taken daily for two years or more.

If medical treatment fails then, one should consider surgical options. Anti-reflux operations are aimed at creating an effective barrier to reflux at the gastroesophageal junction There are various types of anti-reflux operations that are successful. Laparoscopic fundoplication is the gold standard for surgical treatment of severe GERD and results in approximately 95 per cent patient satisfaction (World J Gastrointest Surg. 2016 Jan 27).

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Uncontrolled high blood pressure is a serious risk factor for COVID-19 complications

Life is a journey, not a destination! (Dr. Noorali Bharwani)
Life is a journey, not a destination! (Dr. Noorali Bharwani)

We know high blood pressure is a serious condition. If not treated, it can lead to many complications like heart failure, stroke and dementia. There is evidence to show hypertensive patients are more at risk of complications from COVID-19 than those whose high blood pressure is managed with medication.

A combination of medications and lifestyle changes can bring your blood pressure under control and reduce the risk of heart failure, stroke, dementia and COVID-19.

You should buy a blood pressure monitor and learn to take your own blood pressure at home.

An article in the Canadian Medical Association Journal (Monitoring blood pressure at home: guidance for Canadian Patients – CMAJ July 12, 2021) says it is important to buy home blood pressure monitor approved by Hypertension Canada.

The article says, “Most home blood pressure monitors sold commercially (> 85 per cent worldwide) do not measure blood pressure accurately. Hypertension Canada has a list of recommended devices that have been tested, are known to give valid readings and can be recognized in stores by their Recommended by Hypertension Canada logo (https://hypertension.ca/bpdevices).”

The article recommends measuring blood pressure twice in the morning and twice in the evening for seven consecutive days (28 readings total). If your blood pressure is stable then you can monitor your blood pressure every three months. Best thing would be to check with your doctor and follow the recommendations.

What would be considered high blood pressure?

If your blood pressure readings at home average 135/85 or over then you have high blood pressure. You should discuss this with your doctor.

If you have symptoms of a heart attack or stroke then you should call 911.

What can you do to get your blood pressure under control?

First step is to make lifestyle changes. Eat a healthy diet and exercise 30 to 60 minutes daily. If this does not reduce your blood pressure then you need medications. Medications are needed for systolic blood pressure of 160 or higher and diastolic readings of 100 or higher. If this is not taken care of then your risk of heart attack and stoke are high.

This risk is reduced with medications prescribed by your family doctor, combined with home monitoring and lifestyle changes.

What is meant by lifestyle changes?

  1. Eat heart-healthy foods: fruits, vegetables, whole grains, poultry, fish and low-fat dairy foods.
  2. Eat low salt diet: Aim to limit sodium in your diet.
  3. Lose weight: Losing even a little weight can reduce your blood pressure.
  4. Increase physical activity: This reduces blood pressure and helps with stress and weight loss.
  5. Manage stress: Try deep breathing and meditation.
  6. Avoid or limit alcohol: Alcohol can raise blood pressure.
  7. Do not smoke: Tobacco causes blood pressure to rise and plaque to build up quickly in your arteries.

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We shouldn’t take the Delta threat lightly.

Cruise to Alaska. (Dr. Noorali Bharwani)
Cruise to Alaska. (Dr. Noorali Bharwani)

When we are in a crisis situation our thinking tends to go in high gear. We tend to become innovative and look for growth opportunities. We recognise our strengths and weaknesses. We try to find solutions in a hurry. Look at COVID-19 pandemic. It has changed how we think and it has changed the future of health care.

Now that we seem to be getting control of COVID-19, the virus is trying to outsmart us.

When first cases of the SARS-CoV-2 Delta variant were detected in the United Kingdom in mid-April, the nation was getting ready to open up. This had to be delayed. The fear of Delta variant virus has spread all over the world.

These variants seem to spread more easily and quickly than other variants, which may lead to more cases of COVID-19. These variants may be associated with different symptoms. An increase in the number of cases will put more strain on healthcare resources, lead to more hospitalizations, and potentially more deaths.

According to Alberta Health Care website, anyone who has been infected with a variant strain will test positive for COVID-19. Positive tests are screened again for all variants to determine the exact strain. To date, four variants of concern have been identified in Alberta.

B.1.1.7 (Alpha): This variant was first detected in the United States in December 2020. It was initially detected in the United Kingdom. It’s estimated to be around 50 percent more transmissible than the version of the pandemic coronavirus. According to fresh data, two variants now threaten Alpha’s reign: Delta and Gamma. Delta is considered the most concerning variant seen yet.

B.1.351 (Beta): This variant was first detected in the United States at the end of January 2021. It was initially detected in South Africa in December 2020.

P.1 (Gamma): This variant was first detected in the United States in January 2021. P.1 was initially identified in travellers from Brazil, who were tested during routine screening at an airport in Japan, in early January.

B.1.617.2 (Delta): This variant was first detected in the United States in March 2021. It was initially identified in India in December 2020.

There are several reasons why Delta variant is highly dangerous. Mutations in the Delta variant make it replicate faster and evade the body’s immune mechanism. According to WHO, it is the fastest and fittest variant yet. The Delta variant is 50 – 60 per cent more transmissible than Alpha variant which was 50 – 60 per cent more transmissable than the original strain of COVID-19.

One vaccine dose is not enough to protect you. Two doses of vaccine are strongly protective. Two weeks after receiving a second dose, the Pfizer-BioNTech vaccine appeared to provide 79 per cent protection against infection with the Delta variant, compared with 92 per cent protection against the Alpha variant.

Scientists are debating whether we should take a booster dose against Delta variant. This is currently unknown. So far, studies suggest that the current authorized vaccines work on the circulating variants.

The Pfizer, Moderna and AstraZeneca vaccines currently available in Alberta offer protection against infection and may offer protection against severe outcomes with variants. However, the level of protection may vary depending on the variant and the number of doses received.

Viruses constantly change through mutation, and new variants of a virus are expected to occur. Do not lower your guard. Be vigilant. Get vaccinated. Wear a mask. Maintain social distancing and wash your hands frequently.

Take care. It is not over until it is over!

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COVID-19 has contributed significantly to decline in physical and mental health.

River Walk in Lisbon, Portugal. (Dr. Noorali Bharwani)
River Walk in Lisbon, Portugal. (Dr. Noorali Bharwani)

Alberta Medical Association (AMA), as part of advocacy and engagement with the public has a website (albertapatients.ca) which is Canada’s largest online community for patients to share their thoughts.

AMA engages in dialogue with approximately 13,500 Albertans about health care issues. AMA’s latest survey, fielded May 19 to 27, 2021 asked about people’s worries and priorities regarding their health care. AMA received more than 4,700 responses.

AMA recently shared their findings with the members of the association. AMA says, “The results are sobering: lifestyle and livelihoods (for many) have shifted dramatically, contributing to a significant decline in physical and mental health.”

Here are the important points:

  • More than half of respondents (52 per cent) report that their physical health has declined since the start of the pandemic (15 per cent say their health is now much worse). This is up eight per cent since November 2020 and tends to be more prominent in those under the age of 54 years, and those who have a chronic medical condition. The top reasons cited for the decline in physical health are: harder to exercise, fear of going to a health care provider, and not socializing.
  • The impact COVID-19 has had on the mental health of Albertans is troubling. Sixty-four per cent of respondents report a decline in their own mental health since the start of the pandemic.
  • Twenty-three per cent say their mental health is much worse now. This is more common response among women than men, those under the age of 55, and those with a chronic medical condition.
  • Forty-seven per cent struggle with social isolation, while others cite concerns about finances and the security of their jobs, along with concerns for their own or their family’s health.
  • Only seven per cent of respondents say their mental health has improved since the pandemic began.
  • There is anxiety and depression due to care deficit on individuals who are waiting for treatment. Especially patients who are waiting for cancer surgery, chemotherapy, and radiotherapy.

The deterioration in mental and physical wellness that Albertans are reporting may be a prelude of what is to come. With significant financial deficit the government will have to find more money to play catch-up. As COVID-19 retreats, there will be no automatic reset to what was before the pandemic.

An article in the Canadian Medical Association Journal (CMAJ June 7, 2021 – Postpartum mental illness during the COVID-19 pandemic) highlights the difficulties faced by women after child birth. In Ontario, visits for mental health conditions in the postpartum period increased markedly from March 2020.

The authors of the article observed increased use of nonacute care services for postpartum mental health in Ontario during the first few months of the pandemic, suggesting that self-reported mental distress has translated into increased help-seeking for postpartum people.

The authors of the article suggest health systems should focus proactively on patients from high-risk groups, monitor waiting lists for care, and explore creative solutions to expand system capacity, with special attention to postpartum patients who may be experiencing barriers to care. With the extensive use of virtual care, further evidence regarding the safety and effectiveness of virtual treatment for postpartum mental illness should be sought.

As we can see the health care delivery has changed dramatically in the last year and a half. I doubt whether things will return to the old ways. Doctors will have to find creative ways to assess and treat patients.

Take care. Be safe. Don’t take unnecessary chances. The highly contagious Delta COVID-19 is likely to become dominant in Alberta. So, we have to be careful.

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