Author: noorali

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Breast Cancer in Young Women

It is quite common to see young women with breast lump worrying about cancer. This worrying should not be underestimated nor it should be blown out of proportion. Breast cancer in young women is uncommon. Again, one has to define what is young.

Definition of “young” is defined by different researchers as patients younger than 30, 35, 40 or even 50 years. This limits the amount of information you can gather because the number of cancers in each age group is not that high.

Here are few points to remember about young women who present with a breast lump.

Epidemiological studies in the U.S. show that 2.7 per cent of all cases of breast cancer occur in women ages 35 or younger and 0.6 per cent in women younger than age 30. According to a collective review article on this subject in the Journal of the American College of Surgeons (June 2008), women diagnosed at age 35 and younger tend to present at a more advanced stage of breast cancer and have poorer 5-yeare survival than older pre-menopausal women.

There are several concerns to be taken into consideration when a young woman is diagnosed with breast cancer. She will be worried about fertility, she will go into early menopause from the treatment and there will be psychological and emotional toll on the family, especially young children. The young lady will face a significant challenge to maintain her image and sexuality. The young patient needs to be treated as a whole and not as “just another patient with breast cancer.”

These days all patients (what ever their age or illness) are treated by multidisciplinary teams. The teams take into consideration all anxieties which may affect a patient’s treatment and outcome. But certain patients require special care and attention because of the uniqueness of their illness. Young women with breast cancers fall into that category.

Can we predict which young woman will get breast cancer?

The review article says there is currently no accurate tool for predicting breast cancer risk in young women. A Swedish population-based study found 48 per cent of women younger than 40 had a family history of breast or ovarian cancer. Another study has shown that breast cancer is less common in African-American women than Caucasian women but African-American women develop breast cancer at an earlier age and has worse prognosis than Caucasian women.

Why do young women present with later-stage breast cancers?

One of the reasons is that this population group is not screened as vigorously as the older women. Screening mammography is not recommended for women under 40 (low sensitivity and specificity due to dense breasts) and in fact it is controversial to screen women before the age of 50. In the last few years, some studies have discouraged women from doing breast self-examination (BSE). They argue that BSE leads to unnecessary biopsies.

The review article says, “Currently, it is recommended, although not specifically supported in the literature, that women with a family history of pre-menopausal breast cancer should begin mammographic surveillance 10 years before the age that their relative (i.e. mother, sister) was initially diagnosed.”

Some studies recommend doing an ultrasound alone or in combination with mammography to evaluate a breast lump in a young woman. There are other modalities being tried, such as digital mammography and MRI and these methods are showing promising results when one or more test are combined to evaluate a breast lump in a young woman.

The bottom line is, any suspicious dominant breast mass be biopsied even if the tests are negative. This principal applies whether the woman is young or old. Breast cancer in young women is uncommon but a breast lump in that age group should not be ignored but be thoroughly investigated.

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Don’t Tase Me, Bro!

Don’t tase me, bro!

These words were first uttered by Andrew Meyer, a 21-year-old fourth-year undergraduate telecommunications student on September 17, 2007 in a University of Florida lecture hall when he was forcibly escorted from the hall by the security officers because he would not stop questioning U.S. Senator John Kerry. He was pinned down on the floor and was about to be tasered when he spoke these words. Since then these words have become part of our lexicon.

In November, 2007 Robert Dziekanski, a Polish immigrant to Canada was tasered at the Vancouver airport and subsequently died. About two weeks ago, a 17-year old was tasered in Winnipeg and subsequently died. Death after being tasered has been reported many a times. “In fact, media reports to date have documented over 300 such deaths, 20 in Canada. Critics charge that tasers are too dangerous, that independent studies evaluating their safety are urgently needed and that a moratorium should be placed on their use,” says an article in the Canadian Medical Association Journal (CMAJ).

But Taser International (makers of Taser) has always maintained that taser is not directly responsible for any deaths. It has never been proven in a court of law that taser has directly killed anybody. The company says that taser cannot stop the heart. United Nations has classified the taser as a form of torture.

A news item in the July 15, 2008 issue of the CMAJ says, “Taser International Inc. suffered its first product liability suit loss in roughly 70 instances after a California district court ruled that it was 15 per cent responsible in the death of a 40-year-old drug suspect who died after receiving simultaneous shots from 3 tasers used by police officers. The jury awarded US$1.02 million in compensatory damages, as well as US$5.2 million in punitive damages, for Taser International’s failure to inform police that extended exposure to electric shock from the device could lead to cardiac arrest. The company said it plans to appeal the decision.”

Taser International and law enforcing agencies consider Taser as a valuable tool for subduing criminals and safeguarding the lives of law enforcement personnel. Others consider this as a potentially lethal weapon. What does medical science think?

In the May 20, 2008 issue of the CMAJ, taser is described as “an emerging and increasingly popular medical device.” The review article in the CMAJ says that Taser has potentially lethal effects in animals and humans. But Taser International says that Taser is safe and has sponsored research to prove this point. Has any independent medical research institution sponsored research to prove this point?

Taser International says that taser does not kill but a medical condition; “excited delirium” kills the person after being zapped by a taser. Excited delirium is not a recognized clinical condition. But it is being suggested by certain people that taser should be used to treat excited delirium. Does that mean taser now be considered a medical device? Can taser satisfy rigorous scientific standards through clinical trials before it is accepted as a medical device?

CMAJ article says, “New and independent research, both epidemiologic and biological, into whether tasers can kill is essential to settle this issue. Also, law enforcement agencies could be made to open up their databases on taser use for independent analysis, on the principle that the assertion that tasers have saved lives of police and suspects alike, while plausible, should be proven, not merely asserted as fact.”

I wonder when will this happen. In the meantime, don’t tase me, bro!

Start reading the preview of my book A Doctor's Journey for free on Amazon. Available on Kindle for $2.99!

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Effect Of Exercise On Weight Loss

Well, is there anyone out there who does not want to lose weight?

May be a few. But the vast majority of the people are overweight. And many of them are trying to lose weight. They jump from diet to diet and get frustrated. They try different kinds of exercises and eventually give up because they cannot sustain the discipline of life long healthy eating and exercising.

For many years there has been a debate about the best diet for weight loss. Any diet will work for you if you stick to the demands of the diet. Variety is the spice of life hence people get tired of eating the same sort of food everyday. They need to go out with family members and friends to try different dishes. Many people find wining and dinning satisfying and socially invigorating. Most diets eventually become boring and monotonous.

Doing regular exercise is essential part of any weight loss program. Once people achieve their weight loss then they lose the enthusiasm and slack off. That is when they start putting on weight.

So, the question is how much exercise do you have to do to maintain the weight loss?

“Effect of Exercise on 24-Month Weight Loss Maintenance in Overweight Women,” is an article which was recently published in the Archives of Internal Medicine. For two years the authors of the article studied 201 overweight and obese women with body mass index of 27 to 40, with age range of 21 to 45 years.

The participants were told to reduce calorie intake to 1200 to 1500 calories per day. They were also randomized to one of four physical activity intervention groups based on energy expenditure (either 1,000 calories or 2,000 calories burned per week) and exercise intensity (high vs. moderate).

The results were interesting.

They found weight loss did not differ among the randomized groups. At six months the weight loss was about 10 per cent of initial body weight. At 24 months the weight loss was five per cent of initial body weight.

They also found that by the end of the 24-month intervention, the women who managed to lose at least 10 per cent of their starting body weight and managed to keep it off were exercising twice as long as and burning more than twice as many calories through exercise as women who had no change in body weight. More they exercised, more they lost weight. Women who lost the most weight exercised 68 minutes a day, five days a week.

One of the conclusions was: exercise was more strongly associated with weight loss than any other factor, including diet. Over an hour of sustained exercise most of the days is required to burn enough calories to maintain weight loss. This should be combined with reduced calorie intake. Conventional advice of half-an-hour of moderate exercise does not help lose weight nor maintain weight loss.

The biggest challenge is to stick to a healthy weight reducing diet and overcome obstacles to regular exercise. One way to avoid slacking off is to join some existing programs or get few friends together and form a group of your own – call it “a happy hour group”.

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Tobacco Dependence Can Be Treated

“The World Health Organization estimates that, around the globe, 1.3 billion smokers purchase 10 million cigarettes every minute, and that every 8 seconds somebody dies from a tobacco-related disease,” Canadian Medical Association Journal (June 15, 2008).

Smoking is the single most preventable cause of death and disability. This has been said over and over again for many years. But smokers continue to smoke and each year we find new generation of smokers take up the habit. They get addicted and dependent on the tobacco to an extent that they find it difficult to give up the habit. In consequence they pay a price in terms of health and suffering. Not to mention the amount of money they spend to buy cigarettes and then to buy medications to treat complications of chronic smoking.

June 15 issue of the Canadian Medical Association Journal (CMAJ) has articles that review the “effective treatment for the ultimate vector of this epidemic: tobacco dependence.”

There are several effective medications available for the treatment of tobacco dependence but the problem is a failure of “dissemination of interventions from clinical trials to the broad population of tobacco users.”

Authors of one article in the CMAJ identified 69 well-designed randomized controlled trials which looked at the effectiveness of medications to help tobacco abstinence at six months and 12 months. The authors observed that varenicline (Champix), bupropion (Zyban) and 4 types of nicotine replacement therapy (nasal spray, patch, gum and tablet) roughly doubled the odds of smoking abstinence compared with placebo.

What about the nicotine inhaler?

Nicotine inhaler appeared to double the odds of abstinence as well, but the results were not statistically significant. Nicotine is also available as lozenges and nicotine sublingual tablets which dissolve under the tongue. Even in the US, 2008 guidelines on this subject agree with the above findings. The authors of the commentary in the CMAJ asks, “So why are we not doing a better job controlling the tobacco epidemic?”

The authors say that the answer is simple. It resides in our inability to disseminate effective interventions from the clinical research setting to the population. The authors give several reasons for this failure. At the physician and clinical level there is a primary emphasis on medically urgent issues, lack of time and support, inadequate training and low self-confidence among providers, and low rates of reimbursement for tobacco-treatment services.

At the population level, the authors say there is a lack of political will to restrict tobacco companies and to promote and disseminate the most effective tobacco control policies (e.g., smoke-free indoor air policies and higher tobacco taxes). Sometimes the politicians give low priority to anti-smoking programs and divert funds to other ventures.

One survey has shown that smokers in general will be receptive to receiving free nicotine replacement therapy and would use it to quit smoking. The question remains, how are we going to make the treatment accessible and affordable so we can prevent death and disability from tobacco-related illnesses? The all powerful multinational tobacco industry will not do it for us. The responsibility is in the hands of the government and the clinicians to target and encourage smokers to seek help. And the smokers should know there is help, if only they would ask.

Remember, every eight seconds somebody dies from a tobacco-related disease.

Start reading the preview of my book A Doctor's Journey for free on Amazon. Available on Kindle for $2.99!